News Updates
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Catalyst

Thu, May 28, 2026

1 updates
IONS
4:45 AM

Ionis partner GSK announces bepirovirsen achieves unprecedented functional cure rates with potential to redefine treatment for chronic hepatitis B

– Pivotal B-Well data show significant 19% functional cure rate in the overall study population and 26% in patients with lower viral activity, compared to 0% with standard of care – – 49% of bepirovirsen recipients achieved a surface antigen level of ≤100 IU/mL one year after end of treatment in

Trial Results • Phase 3B-Well 1 and 2 pivotal data readout Thu, May 28, 2026ionis.com

Thu, May 14, 2026

1 updates
IONS
7:05 AM

Ionis partner Biogen announces topline results from Phase 2 CELIA study of diranersen (BIIB080): first study to show reduction in tau pathology and cognitive benefit in patients with early Alzheimer’s disease

- Based on the strength of the biomarker and efficacy data, Biogen plans to advance diranersen to registrational development; CELIA did not meet its primary endpoint assessing dose response - - Robust reductions in tau pathology were observed across all studied doses, with results generally

Trial Results • Phase 2Results event Thu, May 14, 2026ionis.com